0130 Reduced Entropy in EEG During Rapid Eye Movement Sleep in Men with Depression

نویسندگان

چکیده

Abstract Introduction Depression is an increasingly prevalent mental health condition. Patients with depression have disrupted rapid eye movement (REM) sleep as characterized by shortened REM latency, increased duration, and density. However, it unknown whether the dynamic patterns of EEG within episodes are altered in these patients. Here we investigated complexity during using analysis irregularity on multiple temporal time scales compared difference such a nonlinear property between patients controls. Methods We analyzed overnight recordings (256 Hz) collected from left central channel 19 older men age-matched otherwise healthy control Osteoporotic Fractures Men Study (MrOS) obtained National Sleep Research Resource (NSRR). To quantify irregularity/complexity fluctuations REM, Multiscale Entropy (MSE) was performed each 30-second epoch to calculate entropy at different ~0.004 ~0.078 seconds (i.e., 1/256, 2/256, …, 20/256 seconds). Results As men, had significantly lower values 0.023-0.031 (time scale =6/256 second: 0.363□0.008 [SE] for depression, 0.408□0.009 controls; =7/256 0.295□0.009 0.342□0.008 =8/256 0.225□0.009 0.269□0.008 all FDR-adjusted P-values< 0.001), indicating reduced fluctuations. The differences were not statistically significant smaller or larger scales. Conclusion complexity/irregularity depression. Our results indicate capability MSE capturing important features fluctuations, which might be missed those algorithms focused single scale. Support (if any) RF1AG059867, RF1AG064312. Heart, Lung, Blood Institute provided funding ancillary MrOS Study, "Outcomes Disorders Older Men," under following grant numbers: R01 HL071194, HL070848, HL070847, HL070842, HL070841, HL070837, HL070838, HL070839. NSRR supported (R24 HL114473, 75N92019R002).

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Rapid eye movement sleep is reduced in prolactin-deficient mice.

Prolactin (PRL) is implicated in the modulation of spontaneous rapid eye movement sleep (REMS). Previous models of hypoprolactinemic animals were characterized by changes in REMS, although associated deficits made it difficult to ascribe changes in REMS to reduced PRL. In the current studies, male PRL knock-out (KO) mice were used; these mice lack functional PRL but have no known additional def...

متن کامل

Rapid Eye Movement Sleep

• Rapid eye movement (REM) sleep was first identified by its most obvious feature: rapid eye movements occurring during sleep. In most adult mammals the electroencephalogram (EEG) of the neocortex is low in voltage during REM sleep. The hippocampus exhibits regular high-voltage theta waves throughout REM sleep. • The key brain structure for generating REM sleep is the brainstem, particularly th...

متن کامل

Alterations in pattern of rapid eye movement activity during REM sleep in depression.

The aim of the study was to evaluate REM sleep parameters, especially the temporal characteristics of rapid eye movement activity, in depressed patients, and to compare three different methods for scoring of REM density. The sleep of 15 nonmedicated depressed patients and 13 healthy controls was recorded during two consecutive nights. Sleep recordings were scored by raters blinded to the diagno...

متن کامل

Rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis—an observational study

Introduction. Sleep disturbances are commonly found in patients in the postoperative period. Sleep disturbances may give rise to several complications including cardiopulmonary instability, transient cognitive dysfunction and prolonged convalescence. Many factors including host inflammatory responses are believed to cause postoperative sleep disturbances, as inflammatory responses can alter sle...

متن کامل

Sex-selective QT prolongation during rapid eye movement sleep.

BACKGROUND We examined the effects of the various sleep stages on RR and QT intervals in healthy subjects and tested the hypothesis that there is a differential effect of sleep stage on QT interval in women compared with men. METHODS AND RESULTS Eighteen healthy subjects (9 women, age 22 to 45 years) underwent polysomnography and simultaneous recording of ECG, blood pressure, and respiration....

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Sleep

سال: 2023

ISSN: ['0302-5128']

DOI: https://doi.org/10.1093/sleep/zsad077.0130